Here is a great post from Gerry McGovern about how users read web pages: http://www.cmswire.com/cms/web-content/block-reading-how-we-read-on-the-web-003255.php
General guidelines to keep in mind:
- Place the local/second level navigation in the left column
- Put the logo in the top left and link it to home
- In the navigation that runs across the top of the page (global navigation) place a link to Home as the first link, and also include a Contact link.
- If you are dealing with a top task, it should be startable on the homepage, and there may be multiple links to it on the page.